Diabetes increases neuritic damage around amyloid plaques in Alzheimer’s disease

New research from the University of Eastern Finland explores the role of diabetes in the cellular and molecular changes underlying Alzheimer’s disease (AD). In an AD mouse model, diabetes induced through a diet rich in fats and sugars weakened the accumulation of microglial cells around amyloid plaques and increased the formation of neuritic plaques with […]

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Young asymptomatic ‘super spreaders’ keep malaria viable by infecting local mosquitoes

Malaria researchers, working in an area of Uganda where infections have been dropping dramatically, discovered a small number of infected but asymptomatic school-age children can serve as stealth “super spreaders” responsible for the vast majority of malaria parasites still circulating in local mosquitoes. The new findings, reported today at the Annual Meeting of the American […]

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Children with familial hypercholesterolemia are diagnosed late and under-treated

Children born with a common genetic condition, familial hypercholesterolemia (FH), are at increased risk for atherosclerotic cardiovascular disease (ASCVD) early in life. Despite long-standing national guidelines, cholesterol screening—for children at age 2 for those with a family history of heart disease and between the ages of nine to 11 for all children—is not being implemented […]

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Proteogenomics enhances the identification of therapeutic vulnerabilities in breast cancer

Researchers at Baylor College of Medicine, the Broad Institute of MIT and Harvard and other institutions have applied powerful proteogenomics approaches to better understand the biological complexity of breast cancer. With this approach, the researchers were able to propose more precise diagnostics for known treatment targets, identify new tumor susceptibilities for translation into treatments for […]

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